Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats
نویسندگان
چکیده
The systemic toxicity of different combinations of heavy metal mixtures (HMMs) was studied according to equivalent proportions of the eight most common detectable heavy metals found in fish consumption in the Ningbo area of China. The ion mass proportions of Zn, Cu, Mn, Cr, Ni, Cd, Pb, and Hg were 1070.0, 312.6, 173.1, 82.6, 30.0, 13.3, 6.6, and 1.0, respectively. In this study, 10 experimental groups were set as follows: M8 (Pb + Cd + Hg + Ni + Cu + Zn + Mn + Cr); M5 (Pb + Cd + Hg + Ni + Cr); M4A (Pb + Cd + Hg + Ni); M4B (Cu + Zn + Mn + Cr); M3 (Cu + Zn + Mn); Cr; Cu; Zn; Mn; and control. Sprague Dawley (SD) rats were orally treated with a single dose of each group every three days (10 times in total) for 34 days. After Morris water maze test, blood and tissue samples were collected to obtain biochemical, histopathological and western blot analysis. Results show abnormalities could be observed in different treatment groups, the M4B combination had the most significant change compared to all other groups. In conclusion, combination HMMs may have adverse effects on the hematologic, hepatic, renal and neurobehavioral function, and may also disturb electrolyte and lipid balance. Why M4B combination generated much higher toxic effects than any other combination mixtures or individual heavy metal needs to be further evaluated.
منابع مشابه
Repeated administration of cannabinoid receptor agonist and antagonist impairs short and long term plasticity of rat’s dentate gyrus in vivo
Introduction: The effects of cannabinoids (CBs) on synaptic plasticity of hippocampal dentate gyrus neurons have been shown in numerous studies. However, the effect of repeated exposure to cannabinoids on hippocampal function is not fully understood. In this study, using field potential recording, we investigated the effect of repeated administration of the nonselective CB receptor agonist WIN5...
متن کاملToxicity assessment of high fructose corn syrup-55: a repeated dose oral toxicity study in uterus and ovaries of female rats
Background: High-fructose corn syrup-55 (HFCS-55) is a common sweetener in the food industry. Recently, we have investigated and published the effects of uncontrolled long-term oral ingestion of 55-HFCS compared to sucrose on primary ovarian insufficiency in female rats. This study aimed to compare the effects of short-term controlled HFCS-55 administration with sucrose and its possible effects...
متن کاملAcute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats
Iron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. This study aimed to investigate the acute toxicity effects of IONPS in laboratory animals regarding p...
متن کاملAcute and Repeated Dose Toxicity Assessment of Kelussia Odoratissima Mozaff Essential Oil in Female Rat
Background: We aimed in this study to evaluate the acute and repeated dose toxicity of Kelussia odoratissima Mozaff (Kelussia) identified as a rare medicinal plant species which grows in western parts of Iran with potential nutraceutical applications. Materials and Methods: To determine the clinical, hematological, biochemical, necropsy and histopathological effects of the herb’s essential oil...
متن کاملEvaluation of acute and sub-acute toxicity of Pinus eldarica bark extract in Wistar rats
Objective: Pinus eldarica (P. eldarica) is one of the most common pines in Iran which has various bioactive constituents and different uses in traditional medicine. Since there is no documented evidence for P. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of P. eldarica bark were investigated in male and female Wistar rats in this study. Materials and Method...
متن کامل